EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery

NARecruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

July 28, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Electrical Impedance Tomography (EIT)Postoperative Pulmonary Complications (PPCs)RecruitmentMechanical Ventilation ComplicationObesity
Interventions
DEVICE

Group P-eit

"The Recruitment Maneuver - PEEP Titration - Recruitment Maneuver (RM-T-R) Strategy will be implemented 5 minutes after endotracheal intubation. The patient will receive an RM (peak pressure 50cm H2O, PEEP 25cmH2O, respiratory rate 6 bpm, for 10 cycles) followed by a decremental PEEP titration, during which PEEP is set to 25cm H2O and decreased stepwise by 2cm H2O every 3min until reaching 5 cmH₂O. Meanwhile, the ventilator parameters (tidal volume, respiratory rate, and inspiratory-to-expiratory ratio) will be adjusted back to their pre-recruitment settings. EIT-based optimal PEEP is defined as the crossing point of the overdistension and collapse curves during a decremental PEEP trial."

DEVICE

Group P-8

In group p-8, mechanical ventilation will be administered in volume-controlled mode with a tidal volume of 8 ml/kg (based on ideal body weight). Additional settings include a PEEP of 8 cmH₂O, FiO₂ of 0.5, an inspiratory-to-expiratory ratio of 1:2, and a respiratory rate of 12 breaths/min. A recruitment maneuver (RM) will be performed 5 minutes after intubation and again after surgery, using the same protocol as in group P-eit. The respiratory rate will be adjusted as needed to maintain end-tidal CO₂ between 35 and 45 mmHg throughout the procedure.

Trial Locations (1)

0531

RECRUITING

The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan

All Listed Sponsors
lead

Jianbo Wu

OTHER

NCT07207772 - EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery | Biotech Hunter | Biotech Hunter