144
Participants
Start Date
August 30, 2025
Primary Completion Date
August 31, 2026
Study Completion Date
December 31, 2026
Oral Vancomycin
Oral vancomycin in capsule form will be administered three times daily for 5 days at 250mg per dose. Because oral vancomycin is a non-absorbable antibiotic, the likelihood of systemic absorption is minimal and therefore, it is not associated with the adverse events attributable to the intravenous formulation
VE818
VE818 is an 11-strain bacterial consortium rationally designed by Vedanta Biosciences Inc., to displace enteropathogens and reduce intestinal inflammation in pregnant women.
Placebo
Enteric capsules filled with approximately 400mg of microcrystalline cellulose (bulking agent)
RECRUITING
Mother and Child Health Research and Training Center, AKU, Matiari
Bill and Melinda Gates Foundation
OTHER
International Centre for Diarrhoeal Disease Research, Bangladesh
OTHER
University of Zambia
OTHER
Institut Pasteur de Dakar
OTHER
Aga Khan University
OTHER