Selenium Supplementation for Improving Depression in Children and Adolescents: Efficacy and Mechanistic Study

In this intervention, patients will receive adjunctive selenium yeast supplementation at a daily dose of 100-200 μg in addition to fluoxetine. Symptom rating scales, biospecimen collection, and brain MRI will be conducted at baseline, week 4, and week 8 to investigate the adjunctive role of selenium in fluoxetine treatment for depression.

In this intervention, patients will receive standard fluoxetine treatment combined with placebo yeast supplementation (100-200 μg/day), which is identical in appearance and odor to selenium yeast. The aim is to clarify the specific role of selenium in the treatment of depression.