A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection

"Arm A includes treatment with one of three treatment dose antibiotic options, selected by the treating clinician, in combination with methenamine hippurate. Participants allocated to this arm will receive combination therapy, consisting of one of the following antibiotics:~* Cefalexin (500mg four times daily), or~* Nitrofurantoin (100mg twice daily), or~* Trimethoprim (200mg twice daily) in combination with Methenamine Hippurate (1g twice daily) for 12 weeks."

"Arm B includes treatment with one of four prophylactic dose antibiotics or methenamine hippurate, but not both, selected by the treating clinician. Participants in this arm will receive monotherapy of one of the following:~* Amoxicillin (250mg once daily), or~* Cefalexin (125mg once daily), or~* Nitrofurantoin (50mg once daily), or~* Trimethoprim (100mg once daily), or~* Methenamine Hippurate (1g twice daily) for 12 weeks."