Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 8, 2025

Primary Completion Date

April 9, 2028

Study Completion Date

April 9, 2028

Conditions
Prostate CarcinomaRecurrent Prostate Carcinoma
Interventions
DRUG

Antiandrogen Therapy

Given ADT

BEHAVIORAL

Behavioral Intervention

Receive fasting reminders via Oncpatient Companion Mobile Application

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Cardiac Computerized Tomographic Angiography

Undergo a coronary computerized tomography angiography

PROCEDURE

Computed Tomography

Undergo CT

OTHER

Electronic Health Record Review

Ancillary studies

OTHER

Internet-Based Intervention

Complete survey and food diary collection via Oncpatient Companion Mobile Application

BEHAVIORAL

Lifestyle Counseling

Receive diet and lifestyle counseling

OTHER

Medical Device Usage and Evaluation

Wear an activity tracker

OTHER

Nutritional Intervention

Receive AHA HHD guidelines

OTHER

Nutritional Intervention

Receive AHA Life Essential 8 recommendations with personalized caloric intake

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Radiation Therapy

Undergo RT

OTHER

Referral

Receive a referral to an endocrinologist

DRUG

Semaglutide

Given SC

OTHER

Short-Term Fasting

Participate in an overnight fast

DRUG

Tirzepatide

Given SC

Trial Locations (1)

91010

RECRUITING

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER