Combined Gastrointestinal Decontamination in Acute Severe Poisoning

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

November 30, 2027

Study Completion Date

November 30, 2027

Conditions
Severe Poisoning With Cardiotropic or Psychotropic DrugAdmission to Intensive Care
Interventions
DRUG

Combination of activated charcoal with polyethylene glycol for digestive decontamination

"A dose of 25-100g of activated charcoal via the nasogastric tube will be administered, followed by polyethylene glycol1L/15-20 kg ideal body weight at a flow rate of 1L/hour.~polyethylene glycol will be continued until clear stools are obtained, a maximum of 24h of treatment of until the maximum dose of 1L per 15 kg of ideal body weight are administered.~Serial activated charcoal 50g 6 times/day will be administered if prolonged-release forms or drugs with enterohepatic circulation were ingested."

DRUG

Standard Treatment (Guideline-Based)

Patients receive activated charcoal according to French guidelines - activated charcoal 25-100g and serial activated charcoal 50g 6 times/day if sustained-release forms or drugs with enterohepatic circulation as routine treatment.

Trial Locations (1)

75010

Sebastian Voicu, Paris

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER