100
Participants
Start Date
January 9, 2023
Primary Completion Date
June 18, 2025
Study Completion Date
August 30, 2025
Pistacia lentiscus Oil Nasal Drops (Bactorinol®)
Bactorinol® nasal drops (medical device containing ultra-fractioned and winterized Pistacia lentiscus oil). Participants will receive isotonic saline nasal wash plus 5 drops per nostril twice daily for 30 days, followed by 5 drops per nostril twice daily for 15 days per month for the subsequent 11 months.
Placebo Nasal Drops (matched to Bactorinol®)
Placebo nasal drops identical in appearance and administration to Bactorinol®. Participants will receive isotonic saline nasal wash plus placebo drops, 5 drops per nostril twice daily for 30 days, followed by 5 drops per nostril twice daily for 15 days per month for the subsequent 11 months.
Ent Clinic ASST Settelaghi, University of Insubriae, Varese
Università degli Studi dell'Insubria
OTHER
Liaquat University of Medical & Health Sciences
OTHER