Treatment of SSD With tcVNS and taVNS

NANot yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
Somatic Symptom DisorderAnxietyDepressionTranscutaneous Vagus Nerve StimulationNeuromodulation
Interventions
DEVICE

gammaCore Sapphire

This intervention utilizes transcutaneous cervical Vagus Nerve Stimulation (tcVNS). A conductive gel is applied to the device's stimulation surfaces. The device is then placed on the neck over the vagus nerve. The daily treatment protocol consists of three consecutive 2-minute stimulations on the left side of the neck, with a 30-60 second interval between each stimulation. After a brief rest of approximately one minute, the same procedure is repeated on the right side of the neck. The total daily session duration is approximately 20 minutes. Stimulation intensity is individually titrated for each participant to a level that is perceptible but not painful. This regimen is administered once daily for 10 sessions over a 2-week period.

DEVICE

Nurosym

This intervention utilizes transcutaneous auricular Vagus Nerve Stimulation (taVNS). The device consists of an earpiece electrode that is clipped onto the left tragus. A small amount of water is applied to the skin for conductivity. The daily treatment protocol consists of one continuous 30-minute stimulation session. Stimulation intensity is individually titrated for each participant to a level that is perceptible but not painful. This regimen is administered once daily for 10 sessions over a 2-week period.

Trial Locations (1)

640

Department of Psychiatry, National Taiwan University Hospital Yunlin Branch, Douliu, Yunlin

All Listed Sponsors
collaborator

Industrial Technology Research Institute, Taiwan

OTHER

lead

National Taiwan University Hospital

OTHER

NCT07198542 - Treatment of SSD With tcVNS and taVNS | Biotech Hunter | Biotech Hunter