A Study of YL242 in Subjects With Advanced Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

424

Participants

Timeline

Start Date

September 22, 2025

Primary Completion Date

September 30, 2028

Study Completion Date

November 30, 2028

Conditions
Advanced Solid Tumor
Interventions
DRUG

YL242

The YL242 drug product is provided as a lyophilized powder containing 200 mg of YL242 in a glass vial. The initial dose of YL242 will be infused IV into each patient for 90±10 minutes. If there is no infusion-related reaction after the initial dose, the second and subsequent doses of YL242 will be infused IV into each patient for 60±10 minutes.

DRUG

YL242; Pembrolizumab

The YL242 drug product is provided as a lyophilized powder containing 200 mg of YL242 in a glass vial. The initial dose of YL242 will be infused IV into each patient for 90±10 minutes. If there is no infusion-related reaction after the initial dose, the second and subsequent doses of YL242 will be infused IV into each patient for 60±10 minutes. Pembrolizumab will be administered subsequent to YL242.

DRUG

YL242; 5-FU; LV

"The YL242 drug product is provided as a lyophilized powder containing 200 mg of YL242 in a glass vial. The initial dose of YL242 will be infused IV into each patient for 90±10 minutes. If there is no infusion-related reaction after the initial dose, the second and subsequent doses of YL242 will be infused IV into each patient for 60±10 minutes.~LV and 5-FU will be sequentially administered following YL242."

DRUG

YL242; Pembrolizumab; 5-FU

"The YL242 drug product is provided as a lyophilized powder containing 200 mg of YL242 in a glass vial. YL242 will be administered via Intravenous (IV) Infusion.~Pembrolizumab and 5-FU will be administered in sequence after YL242."

Trial Locations (15)

2010

NOT_YET_RECRUITING

AUS-102, Darlinghurst

2170

NOT_YET_RECRUITING

AUS-101, Liverpool

3065

NOT_YET_RECRUITING

AUS-104, Fitzroy

3084

NOT_YET_RECRUITING

AUS-103, Heidelberg

6009

NOT_YET_RECRUITING

AUS-105, Nedlands

34232

NOT_YET_RECRUITING

US-202, Sarasota

37203

NOT_YET_RECRUITING

US-205, Nashville

49546

NOT_YET_RECRUITING

US-206, Grand Rapids

77030

NOT_YET_RECRUITING

US-203, Houston

78229

NOT_YET_RECRUITING

US-207, San Antonio

150081

NOT_YET_RECRUITING

CN-303, Harbin

200030

RECRUITING

CN-301, Shanghai

310022

NOT_YET_RECRUITING

CN-302, Hangzhou

06519

NOT_YET_RECRUITING

US-201, New Haven

02215

NOT_YET_RECRUITING

US-204, Boston

All Listed Sponsors
lead

MediLink Therapeutics (Suzhou) Co., Ltd.

INDUSTRY

NCT07197827 - A Study of YL242 in Subjects With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter