362
Participants
Start Date
September 25, 2025
Primary Completion Date
June 30, 2027
Study Completion Date
August 31, 2027
Pregabalin
For the pregabalin group, treatment will be initiated at a dosage of 150 mg daily, administered into 2 or 3 divided doses. After 3 to 7 days, the dose will be titrated to 300 mg per day, with subsequent incremental increases of 150 mg daily permitted at 3-day to 7-day intervals based on therapeutic response and tolerability, up to a maximum dose of 600 mg daily.
Crisugabalin
For the crisugabalin group, therapy will begin at 20 mg twice daily, with a maximum allowable dose of 40 mg twice daily.
Beijing Tiantan Hospital, Beijing, Beijing 100070, Beijing
China-Japan Friendship Hospital
OTHER
The First Affiliated Hospital of Nanchang University
OTHER
Peking University Third Hospital
OTHER
The Fourth Affiliated Hospital of Harbin Medical University
OTHER
Zhongnan Hospital
OTHER
Xiangya Hospital of Central South University
OTHER
The Affiliated Hospital of Yanbian University
OTHER
Beijing Tiantan Hospital
OTHER