Topical Heparin for Prevention of Hypertrophic Scarring in Split-Thickness Skin Graft Donor Sites

NACompletedINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

August 15, 2024

Primary Completion Date

August 30, 2025

Study Completion Date

September 10, 2025

Conditions
Hypertrophic ScarringPain, PostoperativeWound Healing
Interventions
OTHER

Standard dressing

Intervention Description: Donor site of STSG treated with standard dressing. Wound is cleaned, paraffin gauze applied, covered with gauze pieces and bandaged. Dressing is removed on the 10th post-operative day, or earlier if excessive exudate is present. Pain and wound healing monitored per standard care protoco

OTHER

Topical Heparin Dressing

Intervention Description: Donor site of STSG treated with heparin dressing. 5 ml of 5000 IU/ml heparin is diluted in 50 ml normal saline to produce 500 IU/ml concentration. Gauze is soaked in this solution and applied to donor site immediately after graft harvest. Dressing remains in place until 10th post-operative day unless clinical indication requires earlier change. Pain, wound healing, and hypertrophic scarring assessed during follow-up.

Trial Locations (1)

Unknown

Plastic & Reconstructive Surgery Department, Ruth Pfau Civil Hospita, Karachi

All Listed Sponsors
lead

Dr. Ruth K.M. Pfau Civil Hospital, Karachi

OTHER_GOV

NCT07196358 - Topical Heparin for Prevention of Hypertrophic Scarring in Split-Thickness Skin Graft Donor Sites | Biotech Hunter | Biotech Hunter