10
Participants
Start Date
October 31, 2025
Primary Completion Date
October 31, 2032
Study Completion Date
October 31, 2037
locally manufactured adoptive cellular therapy (ACT) product
Single dose, intrapleural delivery (via indwelling pleural catheter) of adoptive cellular therapy (ACT) product derived from autologous pleural infiltrating T-cells.
Interleukin-2
Low dose Interleukin-2 (IL-2) will also be administered intrapleural at the dose of 20 milliliters (mL) at 1 x 10⁵ International Units (IU)/mL starting approximately 2 hours after ACT infusion and every 8 to 16 hours thereafter, as tolerated, for up to 4 doses (total 8 x 10⁶ IU).
AHN West Penn Hospital, Pittsburgh
Collaborators (2)
Miltenyi Biotec, Inc.
INDUSTRY
Iovance Biotherapeutics, Inc.
INDUSTRY
UPMC Hillman Cancer Center
UNKNOWN
David Bartlett, MD
OTHER