Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

October 31, 2032

Study Completion Date

October 31, 2037

Conditions
Malignant Pleural EffusionMalignant MesotheliomaPleural Effusion, MalignantMetastasis to Pleura
Interventions
BIOLOGICAL

locally manufactured adoptive cellular therapy (ACT) product

Single dose, intrapleural delivery (via indwelling pleural catheter) of adoptive cellular therapy (ACT) product derived from autologous pleural infiltrating T-cells.

DRUG

Interleukin-2

Low dose Interleukin-2 (IL-2) will also be administered intrapleural at the dose of 20 milliliters (mL) at 1 x 10⁵ International Units (IU)/mL starting approximately 2 hours after ACT infusion and every 8 to 16 hours thereafter, as tolerated, for up to 4 doses (total 8 x 10⁶ IU).

Trial Locations (1)

15224

AHN West Penn Hospital, Pittsburgh

All Listed Sponsors
collaborator

Miltenyi Biotec, Inc.

INDUSTRY

collaborator

Iovance Biotherapeutics, Inc.

INDUSTRY

collaborator

UPMC Hillman Cancer Center

UNKNOWN

lead

David Bartlett, MD

OTHER