NCT07188038View on ClinicalTrials.gov

The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics

NANot yet recruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

July 31, 2027

Study Completion Date

December 31, 2027

Conditions
Respiratory FailureARDS (Acute Respiratory Distress Syndrome)PneumoniaRespiratory Insufficiency
Interventions
PROCEDURE

Low positive end-expiratory pressure

Low (4 cmH2O) positive end-expiratory pressure (PEEP) will be applied during pressure support ventilation. The PEEP level will be kept for 10 minutes prior to data acquisition.

PROCEDURE

Medium positive end-expiratory pressure

Medium (10 cmH2O) positive end-expiratory pressure (PEEP) will be applied during pressure support ventilation. The PEEP level will be kept for 10 minutes prior to data acquisition.

PROCEDURE

High positive end-expiratory pressure

High(16 cmH2O) positive end-expiratory pressure (PEEP) will be applied during pressure support ventilation. The PEEP level will be kept for 10 minutes prior to data acquisition.

Trial Locations (2)

413 45

Central intensivvårdsavdelning, Sahlgrenska University Hospital, Gothenburg

Thorax intensivvårdsavdelning, Område 6, Sahlgrenska University Hospital, Västra Götalandsregionen, Gothenburg

All Listed Sponsors
collaborator

Sahlgrenska University Hospital

OTHER

collaborator

Göteborg University

OTHER

lead

Vastra Gotaland Region

OTHER_GOV