NCT07185438View on ClinicalTrials.gov

Efficacy and Safety of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study

NANot yet recruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

September 15, 2025

Primary Completion Date

March 15, 2026

Study Completion Date

September 15, 2026

Conditions
Depression - Major Depressive Disorder
Interventions
DEVICE

Experimental target rTMS treatment

Participants will undergo MRI-guided identification of the voxel in the left dorsolateral prefrontal cortex (DLPFC) that is most negatively correlated with the functional connectivity of the subgenual anterior cingulate cortex (sgACC) as the stimulation site.

DEVICE

Conventional target rTMS treatment

Participants will undergo MRI-guided identification of the standard F3 target in the dorsolateral prefrontal cortex (DLPFC) as the stimulation site.

DEVICE

Sham stimulation treatment

Participants will receive a sham stimulation treatment designed to simulate the rTMS procedure without generating an effective magnetic field output.

Trial Locations (1)

Unknown

The First Affiliated Hospital of Chongqing Medical University, Chongqing

All Listed Sponsors
lead

First Affiliated Hospital of Chongqing Medical University

OTHER