Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

NARecruitingINTERVENTIONAL
Enrollment

302

Participants

Timeline

Start Date

October 27, 2025

Primary Completion Date

May 22, 2028

Study Completion Date

August 14, 2028

Conditions
Posttraumatic Stress DisorderPTSD
Interventions
BEHAVIORAL

Modular Cognitive Processing Therapy

"CPT is a first-line treatment for PTSD that includes the following core elements: (a) identification of stuck points in thinking that interfere with recovery and (b) using Socratic questioning and a series of Contains the same core elements of CPT, but content is repackaged into modules instead of sessions so that clinicians can select and dose treatment elements according to patient need. Modular CPT contains the same core elements of CPT, but content is repackaged into modules instead of sessions so that clinicians can select and dose treatment elements according to patient need."

BEHAVIORAL

Modular Prolonged Exposure Therapy

PE is a first-line treatment for PTSD that includes the following core elements: (a) in vivo exposure and (b) imaginal exposure to the trauma memory. Modular PE is comprised of the same elements of standard PE, but clinicians select and dose modules (i.e., imaginal exposure, in vivo exposure) based on individual patient need.

BEHAVIORAL

Step Down Treatment

Self-managed treatment will involve receiving a self-help version of the remaining treatment materials and ongoing use of the intervention companion app (CPT Coach or PE Coach).

BEHAVIORAL

Digital Interventions

The prompt will be a text message delivered through VA-approved technology (e.g., PETALS).

BEHAVIORAL

Cognitive Processing Therapy (CPT)

"CPT is a first-line treatment for PTSD that includes the following core elements: (a) identification of stuck points in thinking that interfere with recovery and (b) using Socratic questioning and a series of progressive worksheets to examine stuck points, develop balanced beliefs, and facilitate the experience of natural emotions."

BEHAVIORAL

Prolonged Exposure (PE)

PE is a first-line treatment for PTSD that includes the following core elements: (a) in vivo exposure and (b) imaginal exposure to the trauma memory. In imaginal exposure, participants repeatedly, systematically approach their trauma memory and related thoughts and feelings. In in vivo exposure, participants repeatedly, systematically approach objectively safe people, places, objects, and situations that they avoid because these stimuli remind them of their trauma.

Trial Locations (4)

30904

RECRUITING

Augusta VA, Augusta

48105

RECRUITING

Ann Arbor VA, Ann Arbor

49037

NOT_YET_RECRUITING

Battle Creek VA, Battle Creek

84148

RECRUITING

Salt Lake City VA, Salt Lake City

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

The University of Texas Health Science Center at San Antonio

OTHER

NCT07176273 - Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD) | Biotech Hunter | Biotech Hunter