300
Participants
Start Date
December 5, 2025
Primary Completion Date
March 11, 2030
Study Completion Date
December 2, 2030
Crovalimab
Crovalimab will be administered at a dose of 680 mg (for participants with BW ≥ 40 kilograms \[kg\] to \< 100 kg) or 1020 mg (for participants with BW ≥ 100 kg), as a SC injection, at Weeks 1, 2, and 3 and Q4W from Week 5 onwards.
Placebo
Placebo matching crovalimab will be administered as per the schedule specified in the respective arm.
VKA
Dose administration of VKA will be in accordance with the local prescribing information for the respective product. The VKA regimen will be titrated to a therapeutic target INR based on investigator discretion and local standard of care (SOC).
Hoffmann-La Roche
INDUSTRY