A Study to Evaluate Crovalimab in People With Antiphospholipid Syndrome (APS)

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

December 5, 2025

Primary Completion Date

March 11, 2030

Study Completion Date

December 2, 2030

Conditions
Antiphospholipid Syndrome
Interventions
DRUG

Crovalimab

Crovalimab will be administered at a dose of 680 mg (for participants with BW ≥ 40 kilograms \[kg\] to \< 100 kg) or 1020 mg (for participants with BW ≥ 100 kg), as a SC injection, at Weeks 1, 2, and 3 and Q4W from Week 5 onwards.

DRUG

Placebo

Placebo matching crovalimab will be administered as per the schedule specified in the respective arm.

DRUG

VKA

Dose administration of VKA will be in accordance with the local prescribing information for the respective product. The VKA regimen will be titrated to a therapeutic target INR based on investigator discretion and local standard of care (SOC).

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY