A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

116

Participants

Timeline

Start Date

September 25, 2025

Primary Completion Date

December 30, 2028

Study Completion Date

December 30, 2029

Conditions
Renal Cell Carcinoma (RCC)
Interventions
DRUG

Vorolanib Tablets+Everolimus

Subjects received oral vorinib 200 mg once daily (QD) plus everolimus 5 mg once daily (QD), administered within 30 minutes after breakfast daily. Treatment cycles lasted 28 days and continued until disease progression.

DRUG

Sunitinib

Subjects received oral sunitinib 50 mg once daily (QD) in a 4-week on, 2-week off regimen or a 2-week on, 1-week off regimen until disease progression.

Trial Locations (1)

Unknown

Peking University Cancer Hospital, Beijing

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER