236
Participants
Start Date
September 1, 2025
Primary Completion Date
September 30, 2028
Study Completion Date
September 30, 2028
Conventional treatment
Beside the using of Sivelestat Sodium or placebo, all postoperative care will adhere to each center's standard protocols for type A aortic dissection.
Sivelestat sodium
The daily dose (4.8 mg/kg) is diluted in 48 mL of 0.9 % saline and administered as a continuous intravenous infusion over 24 hours at 2 mL/h (equivalent to 0.2 mg/kg/h) for 72 consecutive hours.
Placebo
An equal volume of placebo-containing only the excipients of sivelestat sodium and diluted to 48 mL with 0.9 % saline-will be infused at 2 mL/h for 72 consecutive hours.
The First Affiliated Hospital of Anhui Medical University, Hefei
Fujian Provincial Hospital, Fuzhou
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) (Guangdong Provincial People's Hospital Affiliated to Southern Medical University), Guangzhou
The University of Hong Kong - Shenzhen Hospital, Shenzhen
The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an
Changhai Hospital of Shanghai, Shanghai
The First Affiliated Hospital of Anhui Medical University
OTHER
Fujian Provincial Hospital
OTHER
The University of Hong Kong-Shenzhen Hospital
OTHER
First Affiliated Hospital Xi'an Jiaotong University
OTHER
Guangdong Provincial People's Hospital
OTHER
Changhai Hospital
OTHER
Shanghai Zhongshan Hospital
OTHER