The PAPYRUS Study: Permanent vs. Absorbable Sutures in PrimarY Repair of Umbilical HerniaS: A Multicentre, Single-blind, Non-inferiority, Randomized Controlled Trial

NANot yet recruitingINTERVENTIONAL
Enrollment

914

Participants

Timeline

Start Date

January 1, 2026

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2030

Conditions
Hernia SurgeryUmbilical Hernia Repair
Interventions
OTHER

Permanent Suture

In both control and intervention groups, an open umbilical hernia repair will be performed based on a standardized surgical technique. Dissection and identification of the fascial defect will be performed in a standardized manner. In the control group, a permanent 0-0 polypropylene suture will be used to close the hernia defect in a transverse or vertical interrupted fashion using either the simple interrupted or the figure-of-eight technique. If the surgeon creates an opening in the umbilical skin or extends the skin incision beyond the paraumbilical incision during the procedure, the participant will be excluded from the study.

OTHER

Absorbable

In both control and intervention groups, an open umbilical hernia repair will be performed based on a standardized surgical technique. Dissection and identification of the fascial defect will be performed. An 0-0 polydioxanone suture (PDS) will be used to close the hernia defect in either a transverse or vertical interrupted fashion using either simple interrupted or figure-of-eight technique. If the surgeon creates an opening in the umbilical skin or extends the skin incision beyond the paraumbilical incision during the procedure, the participant will be excluded from the study.

Trial Locations (5)

Unknown

Royal Alexandra Hospital/University of Alberta, Edmonton

Royal Victoria Hospital, Barrie

London Health Sciences Centre, London

North York General Hospital, North York

Vancouver Coastal Health, Vancouver

Sponsors
All Listed Sponsors
collaborator

North York General Hospital

OTHER

collaborator

Royal Victoria Hospital Of Barrie

UNKNOWN

collaborator

London Health Sciences Centre

OTHER

collaborator

University of Alberta

OTHER

lead

University of British Columbia

OTHER

NCT07156188 - The PAPYRUS Study: Permanent vs. Absorbable Sutures in PrimarY Repair of Umbilical HerniaS: A Multicentre, Single-blind, Non-inferiority, Randomized Controlled Trial | Biotech Hunter | Biotech Hunter