NCT07154316View on ClinicalTrials.gov

Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

August 1, 2028

Study Completion Date

December 30, 2028

Conditions
Colorectal Cancer
Interventions
RADIATION

LCRT

50Gy/25Fx

RADIATION

SCRT

25Gy/5Fx

DRUG

CAPOX

1000mg/m2 bid d1-14

DRUG

PD-1

300mg d1，q3w

DRUG

Celecoxib

200mg, bid

Trial Locations (5)

250014

RECRUITING

The First Affiliated Hospital of Shandong First Medical University, Jinan

350000

RECRUITING

Fujian Provincial Cancer Hospital, Fuzhou

455100

RECRUITING

Anyang Tumor Hospital, Anyang

650118

RECRUITING

Yunnan Cancer Hospital, Kunming

Unknown

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

All Listed Sponsors
collaborator

Anyang Tumor Hospital

OTHER

collaborator

Fujian Cancer Hospital

OTHER_GOV

collaborator

Shandong First Medical University

OTHER

collaborator

Yunnan Cancer Hospital

OTHER

lead

Fudan University

OTHER

NCT07154316 - Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer | Biotech Hunter | Biotech Hunter