Endostatin Adenovirus With Checkpoint Inhibitor in Advanced Head and Neck or Esophageal Cancer

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

August 1, 2027

Study Completion Date

August 1, 2027

Conditions
Esophageal CancerHead and Neck Cancer (H&Amp;Amp;Amp;N)
Interventions
BIOLOGICAL

recombinant human endostatin adenovirus

Recombinant Human Endostatin Adenovirus: Administered via intratumoral injection twice every 3 weeks for a total of eight doses, or until disease progression, the occurrence of unacceptable toxicity, or death from any cause, whichever occurs first.

DRUG

PD-1 Inhibitor

PD-1 inhibitor: Administered via intravenous infusion once every 3 weeks.

Trial Locations (1)

610041

West China Hospital of Sichuan University, Chengdu

All Listed Sponsors
lead

Sichuan University

OTHER