Prevalence of Nocturnal Hypoventilation in Obese Subjects Fiited With Continuous Positive Airway Pressure for Obstructive Sleep Apnea / Hypopnea Syndrome

NANot yet recruitingINTERVENTIONAL
Enrollment

139

Participants

Timeline

Start Date

September 30, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Nocturnal HypoventilationObesitySleep Apnea Hypopnea Syndrome
Interventions
OTHER

Transcutaneous Oxy-Capnography

Patients will be monitored using transcutaneous oxy-capnography to evaluate the prevalence of nocturnal alveolar hypoventilation in these population. Nocturnal alveolar hypoventilation is defined with PTcCO2 \> 49 mmHg more than 10% of the time of capnographic recording.

OTHER

Quality of life questionnaires

"Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and the Patient-Reported Hypoventilation Questionnaire."

OTHER

Arterial gasometry

Arterial blood gas analysis will be performed only in patients presenting nocturnal hypoventilation.

OTHER

Body plethysmography

Plethysmography will be performed only in patients presenting nocturnal hypoventilation. It will be used to measure lung volume and assess pulmonary function. This non-invasive procedure involves the patient breathing into a device that measures changes in pressure within a sealed chamber.

OTHER

Spirometry with reversibility test

The intervention will be performed only in patients presenting nocturnal hypoventilation. Spirometry with a reversibility test will be performed to assess lung function and evaluate the response to bronchodilators. The procedure involves measuring forced expiratory volume and forced vital capacity before and after the administration of a bronchodilator.

OTHER

Clinical examination

Clinical exam will be performed only in patients presenting nocturnal hypoventilation. It will consists of standard interview/clinical examination: vital signs, cardiological, pulmonary, abdominal, neurological examination, search for clinical signs of nocturnal hypoventilation, search for signs of hypoxia/hypercapnia, pulmonary auscultation.

Trial Locations (1)

31059

CHU de Toulouse Hôpital Larrey, Toulouse

All Listed Sponsors
collaborator

Fonds de dotation Agir pour les Maladies Chroniques

UNKNOWN

lead

University Hospital, Toulouse

OTHER

NCT07152990 - Prevalence of Nocturnal Hypoventilation in Obese Subjects Fiited With Continuous Positive Airway Pressure for Obstructive Sleep Apnea / Hypopnea Syndrome | Biotech Hunter | Biotech Hunter