Short-term gluCOCOrticoid in Adult STEROID-sensitive Nephrotic Syndrome: The COCO-ASTEROID Study

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

January 31, 2026

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Idiopathic Nephrotic Syndrome
Interventions
DRUG

Conventional 24-week glucocorticoid regimen

Weeks 1 - 4, Prednisolone 1mg/kg/day (max 80mg); Weeks 5 - 6: Prednisolone 0.8mg/kg/day (max 60mg); Weeks 7 - 8: Prednisolone 0.6mg/kg/day (max 50mg); Weeks 9 - 10: Prednisolone 0.5mg/kg/day (max 40mg); Weeks 11 - 12: Prednisolone 0.4mg/kg/day (max 30mg); Weeks 13 - 16: Prednisolone 0.3mg/kg/day (max 25mg); Weeks 17 - 20: Prednisolone 0.2mg/kg/day (max 15 Weeks 21 - 24: Prednisolone 0.1mg/kg/day (max 10mg).

DRUG

short-term course (12 week) glucocorticoid regimen

Weeks 1 - 4, Prednisolone 1mg/kg/day (max 80mg); Weeks 5-8: Prednisolone 1mg/kg/day (max 80mg) on alternate days; 9-12: Prednisolone 0.5mg/kg/day (max 40mg) on alternate days

Trial Locations (1)

325000

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

All Listed Sponsors
lead

First Affiliated Hospital of Wenzhou Medical University

OTHER