Ensuring Access to Optimal Therapy in CF: The ENACT Study

PHASE4RecruitingINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

June 10, 2025

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
Cystic Fibrosis (CF)
Interventions
DRUG

Elexacaftor / Ivacaftor / Tezacaftor

This study will examine different dosing strategies and outcomes for triple combination CFTR modulator therapy using the drug(s) elexacaftor, tezacaftor, and/or ivacaftor in patients with cystic fibrosis.

OTHER

therapeutic drug monitoring

Participants who consent to the therapeutic drug monitoring study will have their dose adjusted to remain within estimated effective concentrations.

Trial Locations (2)

72205

RECRUITING

Arkansas Children's Hospital, Little Rock

RECRUITING

University of Washington, Seattle

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Arkansas Children's Hospital Research Institute

OTHER