Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages

Not yet recruitingOBSERVATIONAL
Enrollment

120

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 1, 2025

Study Completion Date

December 20, 2025

Conditions
Ciprofol
Interventions
OTHER

It is an observational study without any intervention measures.

All patients will fast for 6 hours and will abstain from drinking for 2 hours preoperatively, with no premedication. Preoxygenation will be performed with an oxygen flow rate of 6 L/min. Ciprofol will be continuously infused via a micropump at a rate of 12 mg/kg/h. During preoxygenation with a facemask, if respiratory depression occurs during ciprofol infusion, assisted ventilation via facemask will be initiated. After LOC and completion of observation indices, the anesthesiologist may administer midazolam (1-3 mg), sufentanil (0.2-0.5 μg/kg), and rocuronium (0.3-0.6 mg/kg) sequentially based on the patient's age, physical condition, and BIS values to complete anesthesia induction. If hypotension (systolic blood pressure \<90 mmHg or \<80% of baseline) or bradycardia (heart rate \<50 beats/min) occurs during induction, vasoactive agents such as ephedrine or atropine will be administered for management.

Trial Locations (1)

Unknown

General Hospital of Ningxia Medical University, Yinchuan

All Listed Sponsors
lead

General Hospital of Ningxia Medical University

OTHER