AssociatiNG Bevacizumab bEmarituzumab for GynecoLogIcal CAncer

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

87

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

October 15, 2030

Study Completion Date

October 15, 2030

Conditions
Endometrial CarcinomaOvarian CancerCervix Cancer
Interventions
DRUG

Bemarituzumab

"Part 1 Dose escalation part :~IV infusion, every 3 weeks with the dose :~DL1 = 15 mg/kg cycle 1 day 1, then 11 mg/kg thereafter from cycle 2 day 1 DL2 = 22 mg/kg cycle 1 day 1, then 15 mg/kg thereafter from cycle 2 day 1 DL3 = 30 mg/kg cycle 1 day 1, then 22 mg/kg thereafter from cycle 2 day 1~Part 2 Extension part :~IV infusion, every 3 weeks with the dose defined in the phase I dose escalation~Treatment with both study drugs will continue until disease progression according to RECIST v1.1, unacceptable toxicity, death, patient or physician decision to withdraw, or pregnancy, whichever occurs first"

DRUG

Bevacizumab

IV infusion, 15mg/kg, every 3 weeks. Treatment with both study drugs will continue until disease progression according to RECIST v1.1, unacceptable toxicity, death, patient or physician decision to withdraw, or pregnancy, whichever occurs first

All Listed Sponsors
lead

Centre Leon Berard

OTHER