The Impact of Olive Oil Polyphenol Supplementation on Metabolic Syndrome Parameters: Preclinical Investigations Have Demonstrated That Olive Oil Polyphenols, Notably Oleocanthal, Oleacein, and Allied Secoiridoids, Possess Anti-inflammatory and Antioxidant Attributes

NACompletedINTERVENTIONAL
Enrollment

106

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

January 1, 2025

Study Completion Date

January 1, 2025

Conditions
Metabolic Syndrome
Interventions
DIETARY_SUPPLEMENT

Olive Oil Polyphenol Supplement (OOPs, OLEOPROTECT®, Thousand Olives®)

Participants receive two capsules daily (total 10 mg/day) of a standardized olive oil polyphenol extract. Each capsule contains 5 mg of aldehydic phenols: 75% oleocanthal/oleacein and 25% oleuropein aglycon/ligstroside aglycon. Formulated with PEG400, cellulose, silicon dioxide, and magnesium stearate. Duration: 12 weeks.

DIETARY_SUPPLEMENT

Placebo capsules

Two capsules taken daily for 12 weeks. Identical in weight, appearance, and taste to the active OOPs capsules. Contain PEG400, cellulose, silicon dioxide, and magnesium stearate, but no active olive oil polyphenols.

Trial Locations (1)

Unknown

Apostolos Loukas Medical Centre Cyprus, Nicosia

All Listed Sponsors
collaborator

University of Nicosia

OTHER

collaborator

University of Crete

OTHER

collaborator

National and Kapodistrian University of Athens

OTHER

collaborator

Yale University

OTHER

lead

Apostolos Loukas Medical Centre Cyprus

NETWORK

NCT07144488 - The Impact of Olive Oil Polyphenol Supplementation on Metabolic Syndrome Parameters: Preclinical Investigations Have Demonstrated That Olive Oil Polyphenols, Notably Oleocanthal, Oleacein, and Allied Secoiridoids, Possess Anti-inflammatory and Antioxidant Attributes | Biotech Hunter | Biotech Hunter