Secretome TGF Beta 3

NANot yet recruitingINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

February 14, 2026

Primary Completion Date

May 14, 2026

Study Completion Date

December 20, 2026

Conditions
Melasma
Interventions
DRUG

Concentrated secretome Injection 3 mL

The secretome used in this research comes from mesenchymal stem cells from adipose tissue produced by Dr. Cipto Mangunkusumo Hospital Stem Cell Medical Technology. The secretome produced by mesenchymal stem cells is collected, centrifuged to separate it from debris, and followed by filtration with a 0.22 μm pore filter to ensure sterility. Next, the concentration process is carried out using tangential flow filtration with the Spin-X UF 500® concentrator, packaged, and stored at -80 degrees Celsius. The product used is a sterile product, which is tested for sterility and total protein content. When it is to be used, the secretome is removed from the freezer, warmed (thawing), and injected into the patient according to a predetermined method.

DRUG

Concentrated secretome Injection 3 mL with addition of TGF Beta 3

The secretome used in this research comes from mesenchymal stem cells from adipose tissue produced by Dr. Cipto Mangunkusumo Hospital Stem Cell Medical Technology. The secretome produced by mesenchymal stem cells is collected, centrifuged to separate it from debris, and followed by filtration with a 0.22 μm pore filter to ensure sterility. Next, the concentration process is carried out using tangential flow filtration with the Spin-X UF 500® concentrator, packaged, and stored at -80 degrees Celsius. The product used is a sterile product, which is tested for sterility and total protein content. When it is to be used, the secretome is removed from the freezer, warmed (thawing), and injected into the patient according to a predetermined method after the secretome is ready, TGF beta 3 will be added to secretome

Trial Locations (1)

10430

Dr. Cipto Mangunkusumo Hospital, Central Jakarta

All Listed Sponsors
lead

Indonesia University

OTHER