Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

October 31, 2027

Study Completion Date

December 31, 2027

Conditions
ACL InjuryACL ReconstructionScar Formation
Interventions
DRUG

Losartan

Two types of losartan capsules will be compounded by combining a broken-up 25mg or 50mg losartan tablet and microcrystalline cellulose placebo filler to eliminate rattling of the broken tablet inside of the capsule. The 25mg losartan capsules will be yellow and the 50 mg losartan capsules will be blue.

OTHER

Placebo

The placebo capsules will consist of microcrystal cellulose and will come in yellow and blue to appear identical to the losartan capsules.

Trial Locations (1)

60612

Rush University Medical Center, Chicago

All Listed Sponsors
collaborator

Arthroscopy Association of North America (AANA)

UNKNOWN

lead

Rush University Medical Center

OTHER