Medium-term Effects of Treatments in Autoimmune Encephalitis

RecruitingOBSERVATIONAL
Enrollment

200

Participants

Timeline

Start Date

September 1, 2024

Primary Completion Date

September 1, 2024

Study Completion Date

March 1, 2027

Conditions
NMDAR Autoimmune EncephalitisLGI1 Antibody Associated EncephalitisCASPR2-AntibodyIgLON5GAD65GFAP
Interventions
OTHER

We aim to assess the clinical response to the treatment initiation protocols most commonly used in autoimmune encephalitis (first-line, first-line with rituximab, dual immunosuppression).

"The patients will be identified via the French Nationwide Multidisciplinary Team Meetings for Autoimmune encephalitis, which are conducted on a bi-monthly basis. All patients with newly diagnosed NMDAR, LGI1, CASPR2, IgLON5, GFAP or GAD65 encephalitis and treated for less than 8 weeks will be included. Treatment protocols at the initiation of therapy will be stratified into: 1) first-line only; 2) rituximab without cyclophosphamide; 3) rituximab combined with cyclophosphamide; 4) others.~The referral clinicians will be contacted by email and the data will be collected using standardized questionnaires, which will be sent at baseline (visit 1, V1) and 4 months after the initiation of therapy (visit 2, V2). The questionnaires will be structured into 7 sections:~* 1 Demographics~* 2 Symptoms~* 3 Cognitive screening tests (MMSE, MoCA, and/or others)~* 4 Level of dependence (ADL, I-ADL, mRS, CASE) and impact on social life~* 5 Diagnostic tests (brain MRI, brain PET, CSF, and EEG findings)"

Trial Locations (1)

69677

RECRUITING

Hospices Civil de Lyon, Bron

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER