Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass

Active, not recruitingOBSERVATIONAL
Enrollment

150

Participants

Timeline

Start Date

May 1, 2025

Primary Completion Date

September 30, 2029

Study Completion Date

September 30, 2029

Conditions
Pulmonary Hypertension
Interventions
DIAGNOSTIC_TEST

blood draw

Research blood draw

DIAGNOSTIC_TEST

Short Performance Physical Battery

test of physical performance, which involves measuring movement from sitting to standing, walking speed, and balance

DIAGNOSTIC_TEST

Grip strength test

Measures grip strength

DIAGNOSTIC_TEST

Six minute walk test

Measures distance walked in 6 minutes

RADIATION

Chest CT scan

X-ray and computer technology takes detailed pictures of the organs and structures inside your chest

RADIATION

Dual-Energy X-ray Absorptiometry Scan

Uses X-ray technology to measure the mineral density of your bones, and provides a ratio of fat tissue to lean mass (muscle) and bone

BEHAVIORAL

Activity monitoring

A device worn on your non-dominant wrist which measures motion/ movement/ activity

BEHAVIORAL

24 hour diet recall

A research dietitian will contact you and ask you to provide details of what you ate over the previous 24 hours

DIAGNOSTIC_TEST

Echocardiogram

Ultrasound technology to create moving images of your heart, valves, and chambers

BEHAVIORAL

Quality of Life Questionnaire (emPHasis 10)

The emPHasis-10 is a pulmonary hypertension-specific questionnaire which is scored from 0-50 (with higher scores indicating worse quality of life.)

BEHAVIORAL

International Physical Activity Questionnaire Short Form (IPAQ-SF)

The IPAQ-SF is a small set of questions to obtain comparable estimates of physical activity.

Trial Locations (1)

19104

University of Pennsylvania Hospital, Philadelphia

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

University of Pennsylvania

OTHER