SFRT+Tislelizumab+Platinum Chemotherapy for Unresectable Stage III NSCLC

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

October 30, 2025

Primary Completion Date

April 15, 2026

Study Completion Date

April 15, 2026

Conditions
Non-Small Cell Lung Cancer
Interventions
OTHER

Spatially Fractionated Radiotherapy (SFRT)

Several spherical volumes (with a diameter of 1 cm) are selected within the hypoxic area of the primary tumor. The distance between each spherical volume is 1.5 - 2 cm, and a high-dose radiotherapy of 12 Gy × 1F is delivered.

DRUG

Tislelizumab, Carboplatin, Pemetrexed

For adenocarcinoma, pemetrexed (500 mg/m², day 1) + carboplatin (AUC 5, day 1) is used.

DRUG

Tislelizumab, paclitaxel, Carboplatin

For NSCLC with pathological types other than adenocarcinoma, nab-paclitaxel (100 mg/m² on day 1 and day 8) + carboplatin (AUC 5, day 1) is used.

Trial Locations (1)

330000

Nanchang City, Jiangxi Province, Nanchang

All Listed Sponsors
lead

Second Affiliated Hospital of Nanchang University

OTHER