Ivonescimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy Followed by Type A Hysterectomy in Stage IB2 and IIA1 Cervical Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

August 31, 2028

Study Completion Date

August 31, 2030

Conditions
Cervical Cancers
Interventions
DRUG

Neoadjuvant Chemotherapy Combined with Immunotherapy

"Drug: Neoadjuvant Chemotherapy paclitaxel, 135-175mg/m2, q3w, 2-3 cycles~Drug: Neoadjuvant Chemotherapy cisplatin, 75-80mg/m2, q3w, 2-3 cycles~Drug: Immunotherapy Ivonescimab, 20mg/kg, q3w, 2-3cycles~Procedure: Type A hysterectomy After 3 cycles of neoadjuvant therapy, patients who achieved CR/PR will undergo Type A hysterectomy + sentinel lymph node dissection / pelvic lymphadenectomy"

Trial Locations (1)

Unknown

RECRUITING

The Obstetrics & Gynecology Hospital of Fudan University, Shanghai

All Listed Sponsors
lead

Obstetrics & Gynecology Hospital of Fudan University

OTHER

NCT07130240 - Ivonescimab Combined With Paclitaxel and Cisplatin as Neoadjuvant Therapy Followed by Type A Hysterectomy in Stage IB2 and IIA1 Cervical Cancer | Biotech Hunter | Biotech Hunter