Efficacy And Safety Of Anti-PD-1/PD-L1 Antibodies In Combination With Bevacizumab And Metronomic Cyclophosphamide In Patients With Non-Small Cell Lung Cancer And Cutaneous Melanoma Previously Treated With Immune Checkpoint Blockade

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

August 14, 2025

Primary Completion Date

August 14, 2025

Study Completion Date

December 31, 2027

Conditions
Metastatic Non-small Cell Lung Cancer (NSCLC)Metastatic Cutaneous Melanoma
Interventions
COMBINATION_PRODUCT

reICB regimen (NSCLC)

"* ICI (one of the following): Atezolizumab 1200 mg every 3 weeks/Nivolumab 240 mg every 2 weeks/Pembrolizumab 200 mg every 3 weeks~* Cyclophosphamide 50 mg PO daily~* Bevacizumab 7.5 mg/kg every 3 weeks"

COMBINATION_PRODUCT

reICB regimen (melanoma)

"* ICI (one of the following): Nivolumab 240 mg every 2 weeks/Pembrolizumab 200 mg every 3 weeks~* Cyclophosphamide 50 mg PO daily~* Bevacizumab 7.5 mg/kg every 3 weeks"

Trial Locations (1)

197022

RECRUITING

EuroCityClinic LLC, Saint Petersburg

All Listed Sponsors
collaborator

First Pavlov State Medical University in St. Petersburg, Russia

UNKNOWN

lead

EuroCityClinic LLC

NETWORK

NCT07130032 - Efficacy And Safety Of Anti-PD-1/PD-L1 Antibodies In Combination With Bevacizumab And Metronomic Cyclophosphamide In Patients With Non-Small Cell Lung Cancer And Cutaneous Melanoma Previously Treated With Immune Checkpoint Blockade | Biotech Hunter | Biotech Hunter