High Dose (HD) Aflibercept Switch in Neovascular Age-related Macular Degeneration (nAMD): to Load or Maintain (HEIRLOOM)

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

August 20, 2025

Primary Completion Date

February 28, 2027

Study Completion Date

February 28, 2027

Conditions
Wet Age-related Macular Degeneration (wAMD)
Interventions
OTHER

Maintenance

Patients who are currently being treated with EYLEA® (aflibercept 2mg) will be switched to EYLEA® HD (aflibercept 8mg) and maintain the current treatment interval that they had with EYLEA® (aflibercept 2mg), followed by an extension of therapy (or increase in treatment dosing interval) based on clinical response

Trial Locations (1)

H1Y0E2

Clinique de Retine de L'Est, Montreal

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Clinique de Retine de l'est

OTHER

NCT07129239 - High Dose (HD) Aflibercept Switch in Neovascular Age-related Macular Degeneration (nAMD): to Load or Maintain (HEIRLOOM) | Biotech Hunter | Biotech Hunter