Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

June 30, 2027

Study Completion Date

December 31, 2027

Conditions
HemorrhageHemorrhagic ShockUpper Gastrointestinal Bleeding (UGIB)
Interventions
DRUG

low-titer O-group whole blood

Arm Description: During the emergency phase, administer 4 units of low-titer group O whole blood (anti-A/B IgM antibody titer \< 1:64); once the patient's blood type is determined, switch to type-specific whole blood.

DRUG

1:1:1 component transfusion

"Following the Chinese Expert Consensus on Emergency Blood Support Models and Transfusion Strategies for Severely Injured Patients (2024 Edition), implement the massive transfusion protocol (MTP) by transfusing type-specific blood components in a 1:1:1 ratio (red blood cells : plasma : platelets)."

DRUG

ABO- and Rh-compatible whole blood

"Administer type-specific whole-blood transfusion in accordance with the Chinese Expert Consensus on Emergency Blood Support Models and Transfusion Strategies for Severely Injured Patients (2024 Edition)."

Trial Locations (1)

710032

Xijing Hospital, Xi'an

All Listed Sponsors
lead

Xijing Hospital

OTHER