A Single-center, Multicohort, Phase II Clinical Study Evaluating the Combination Therapy of Sacituzumab Tirumotecan in Patients With Unresectable, Locally Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 30, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2028

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
DRUG

Sacituzumab Tirumotecan in combination with tislelizumab

"Sacituzumab Tirumotecan 5mg/kg, iv, d1, Q2W ,until disease progression or intolerable toxicity.~Tislelizumab,200 mg, iv, d1, Q3W, until disease progression or intolerable toxicity."

DRUG

Sacituzumab Tirumotecan in combination with anlotinib

"Sacituzumab Tirumotecan 5mg/kg, iv, d1, Q2W ,until disease progression or intolerable toxicity.~Anlotinib 12mg QD po d1-14,Q3W,until disease progression or intolerable toxicity."

All Listed Sponsors
lead

The First Affiliated Hospital of Zhengzhou University

OTHER

NCT07128693 - A Single-center, Multicohort, Phase II Clinical Study Evaluating the Combination Therapy of Sacituzumab Tirumotecan in Patients With Unresectable, Locally Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma | Biotech Hunter | Biotech Hunter