A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or Oligodendroglioma

1 cycle of TNF before resection and 6 cycles after surgery

6 cycles of 28 days with L19TNF and TMZ

6 cycles of 6 weeks of L19TNF and CCNU every 6 weeks

6 cycles of 6 weeks with L19TNF

6 cycles of 28 days with L19TNF (D1, D3, D5) and temozolomide chemotherapy TMZ (D1-5).

6 cycles of 6 weeks of L19TNF (D1, D3, D5, D22, D24 and D26) and CCNU (D1) every 6 weeks

6 cycles of 6 weeks with L19TNF