Post-Radical Treatment Antiviral Strategies in HBV-Related Liver Cancer: Impact on Tumor Prognosis

Not yet recruitingOBSERVATIONAL
Enrollment

332

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2030

Conditions
Hepatocellular Carcinoma (HCC)Chronic Hepatitis B
Interventions
DRUG

Intervention for Group 1

Participants will receive standard NAs therapy, which may include entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), or tenofovir amibufenamide (TMF). NAs are antiviral medications used to suppress HBV replication and manage chronic hepatitis B infection.

DRUG

Intervention for Group 2

Participants will receive Peg-IFNα-2b in addition to NAs therapy. Peg-IFNα-2b is an antiviral medication that works by boosting the immune system and has additional antiviral, antifibrotic, and anti-tumor effects. It is used to treat chronic hepatitis B and may help reduce the recurrence of liver cancer.

All Listed Sponsors
lead

Shenzhen Third People's Hospital

OTHER