1,000
Participants
Start Date
February 1, 2026
Primary Completion Date
January 31, 2029
Study Completion Date
January 31, 2030
Extra 600mg of Rifampicin
Intervention group participants will receive standard treatment (RHZE), plus an optimised regimen consisting of RIfampicin at 20 mg/kg (additional 600mg rifampicin in each weight band) during a shortened treatment period of 16 weeks.
Placebo
The standard treatment regimen for DS-TB (rifampicin at 10 mg/kg and isoniazid for 6 months, plus pyrazinamide and ethambutol for the first 2 months; 2RHZE/4RH), with additional placebo for the first 4 months (16 weeks).
St George's, University of London
OTHER
McMaster University
OTHER
Hamilton Health Sciences Corporation
OTHER