Radiotherapy Combined QL1706, TAS-102 and Bevacizumab in mCRC

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

August 31, 2027

Study Completion Date

December 31, 2028

Conditions
mCRC
Interventions
RADIATION

Palliative radiotherapy

Conventional fractionation, low-dose hypofractionated radiotherapy, or high-dose hypofractionated radiotherapy may be employed.

DRUG

Iparomlimab and tuvonralimab

5 mg/kg, intravenously infused on Day 1 of each cycle, administered every 3 weeks (with each cycle defined as 21 days).

DRUG

TAS-102

35 mg/m², orally twice daily on Days 1 to 5 and Days 8 to 12 of each cycle, with each cycle spanning 28 days (4 weeks).

DRUG

Bevacizumab

7.5 mg/kg via intravenous infusion on Day 1 of each 21-day cycle.

Trial Locations (1)

250000

Jinan Central Hospital, Jinan

All Listed Sponsors
lead

Jinan Central Hospital

OTHER