A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

PHASE2RecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

August 19, 2025

Primary Completion Date

February 8, 2027

Study Completion Date

February 8, 2027

Conditions
Type 2 Diabetes Mellitus
Interventions
DRUG

RO7795081

RO7795081 will be taken orally once daily (QD), according to the randomized dosing regimen, during the 30-week treatment period.

DRUG

Semaglutide

Semaglutide 14 mg will be taken orally QD, with up-titration as per label, during the 30-week treatment period.

DRUG

Placebo

Placebo will be taken orally QD during the 30-week treatment period.

Trial Locations (30)

11516

RECRUITING

Neurobehavioral Research, Inc., Cedarhurst

19114

RECRUITING

Tristar Clinical Investigations, Philadelphia

20009

RECRUITING

Emerson Clinical Research Institute, Washington D.C.

20110

RECRUITING

Manassas Clinical Research Center, Manassas

28401

RECRUITING

Accellacare of Wilmington, LLC, Wilmington

28625

RECRUITING

Accellacare of Piedmont Healthcare, Statesville

30291

RECRUITING

Rophe Adult and Pediatric Medicine/SKYCRNG, Union City

32806

RECRUITING

K2 Medical Research South Orlando, LLC, Orlando

37203

RECRUITING

Clinical Research Associates, Nashville

37909

RECRUITING

Alliance for Multispecialty Research. LLC, Knoxville

41003

RECRUITING

Nuevas Tecnologias en Diabetes y Endocrinologia, Seville

41009

RECRUITING

Universidad de Sevilla - Hospital Universitario Virgen Macarena, Seville

41010

RECRUITING

Hospital Quironsalud Infanta Luisa, Seville

41950

RECRUITING

Hospital Vithas Nisa Sevilla, Castilleja de la Cuesta

45801

RECRUITING

NexGen Research, Lima

59701

RECRUITING

Mercury Street Medical Group, PLLC, Butte

60453

RECRUITING

Accellacare of Duly Health and Care, Oak Lawn

75230

RECRUITING

Velocity Clinical Research, Dallas

76710

RECRUITING

Velocity Clinical Research (Impact Research Institute), Waco

77401

RECRUITING

Apex Mobile Clinical Research, Bellaire

78731

RECRUITING

Texas Diabetes & Endocrinology, P.A., Austin

84790

RECRUITING

Chrysalis Clinical Research, St. George

85712

RECRUITING

Arizona Liver Health - Tucson, Tucson

91730

RECRUITING

Prospective Research Innovations Inc., Rancho Cucamonga

91978

RECRUITING

Encompass Clinical Research, Spring Valley

92630

RECRUITING

Orange County Research Center, Lake Forest

06708-3346

RECRUITING

Chase Medical Research, Waterbury

40-648

RECRUITING

Pro Familia Altera Sp z o.o., Katowice

51-162

RECRUITING

Centrum Bada? Klinicznych, Wroc?aw

08022

RECRUITING

centro Medico Teknon, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT07112872 - A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes | Biotech Hunter | Biotech Hunter