Radiotherapy Omitting Prophylactic Neck Irradiation With Neoadjuvant and Adjuvant Toripalimab in Nasopharyngeal Carcinoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

59

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

August 14, 2029

Study Completion Date

August 14, 2032

Conditions
Nasopharyngeal Cancinoma (NPC)
Interventions
RADIATION

Without prophylactic neck irradiation

Intensity-modulated radiotherapy restricted to the primary tumor, omitting prophylactic neck irradiation.

DRUG

PD-1 antibody (Toripalimab)

Toripalimab 240mg every 2 weeks with a total of 2 cycles as neoadjuvant anti-PD-1 immunotherapy; Toripalimab 240mg every 3 weeks with a total of 8 cycles as adjuvant anti-PD-1 immunotherapy after CCRT

DRUG

Cisplatin

Cisplatin 100mg/m2(every three weeks), Day 1, Day 22, Day 43 of intensity modulated radiotherapy

Trial Locations (1)

510060

Sun Yat-sen Universitty Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER