Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

NARecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

October 15, 2025

Primary Completion Date

July 1, 2026

Study Completion Date

December 31, 2026

Conditions
Parkinson Disease
Interventions
OTHER

Nighttime Deep Brain Stimulation with Varying Amplitude Settings

Participants will undergo three different nighttime-only Deep Brain Stimulation (DBS) settings in a randomized crossover design: 0% amplitude (stimulation off), 50% amplitude of their optimal clinical DBS settings, and full clinical DBS settings (100%). Each setting is applied for two weeks during sleep, over a total six-week home monitoring period. The intervention is designed to assess how varying levels of subthalamic nucleus DBS influence sleep quality and neural oscillatory activity. Only nighttime DBS settings are modified; daytime settings remain unchanged.

Trial Locations (1)

441950001

RECRUITING

Cleveland Clinic, Cleveland

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

American Parkinson's Disease Association, Inc

OTHER

collaborator

Beacon Biosignals

INDUSTRY

lead

The Cleveland Clinic

OTHER

NCT07110376 - Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease | Biotech Hunter | Biotech Hunter