ASKC202 Combined With Limertinib Versus Platinum-based Chemotherapy in Treatment of Locally Advanced or Metastatic NSCLC With MET Amplification/Overexpression After Failure of EGFR-TKI Therapy

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

286

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

October 31, 2027

Study Completion Date

December 31, 2028

Conditions
Locally Advanced or Metastatic NSCLC
Interventions
DRUG

ASKC202+ Limertinib

ASKC202 orally once per day (QD) combined with Limertinib orally BID for every cycle of 21 days until disease progression or other criteria for treatment discontinuation will be met.

DRUG

Pemetrexed + Cisplatin /Carboplatin

The standard chemotherapy treatment of cisplatin/carboplatin combined with pemetrexed on Day 1of 21 day cycles for 4\~6 cycles (every 3 weeks).

Trial Locations (1)

Unknown

Shanghai East Hospital, Shanghai

All Listed Sponsors
lead

Jiangsu Aosaikang Pharmaceutical Co., Ltd.

INDUSTRY

NCT07109531 - ASKC202 Combined With Limertinib Versus Platinum-based Chemotherapy in Treatment of Locally Advanced or Metastatic NSCLC With MET Amplification/Overexpression After Failure of EGFR-TKI Therapy | Biotech Hunter | Biotech Hunter