78
Participants
Start Date
October 31, 2025
Primary Completion Date
January 1, 2028
Study Completion Date
February 1, 2029
Tocilizumab
"Participants will continue Tocilizumab (TCZ) at a lower dose of either 4 mg/kg IV monthly or 162 mg SC every 2 weeks~Participants randomized to the stepped-down treatment arm will receive TCZ on their current route of administration. The route of administration may change if needed during study participation at the discretion of the investigator"
Discontinue Tocilizumab
"Participants will discontinue Tocilizumab and will have visits at Week 2, Month 1 and 2, and then every 2 months during the TCZ Withdrawal Phase until the Month 18 Visit.~Participants who remain in remission will enter the Follow-Up Phase for an additional 12 months at Month 18 and will continue withdrawal at that time."
Hospital for Special Surgery, New York: Division of Rheumatology, New York
Northwell Health: Division of Rheumatology and Allergy-Clinical Immunology, Great Neck
University of Pittsburgh Medical Center: Division of Rheumatology and Clinical Immunology, Pittsburgh
Johns Hopkins Hospital: Division of Rheumatology Vasculitis Center, Baltimore
Emory University School of Medicine: Division of Rheumatology, Atlanta
Northwestern University, Chicago
Massachusetts General Hospital: Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Boston
National Institute of Allergy and Infectious Diseases (NIAID)
NIH