Camrelizumab in Combination With Chemotherapy as Neoadjuvant Treatment in Patients With Early or Locally Advanced Triple-negative Breast Cancer

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 31, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Breast Cancer
Interventions
DRUG

Camrelizumab

200 mg by intravenous (iv.) infusion every 2 weeks (Q2W) for 10 times

DRUG

Doxorubicin +cyclophosphamide+ filgrastimum

Doxorubicin 60mg/m² + cyclophosphamide 600 mg/m² on Day 1 of Cycles 1-4 (Q2W) of the first neoadjuvant phase of the study, IV infusion. filgrastim (G-CSF) subcutaneously on days 2-6 of Cycles 1-4

DRUG

carboplatin + paclitaxel (CP)

carboplatin AUC 2 and paclitacel 80 mg/m² will be given on day 1 every 12 weeks of the second neoadjuvant phase of the study, IV infusion.

All Listed Sponsors
lead

Blokhin's Russian Cancer Research Center

OTHER