HAIC Combined With Camrelizumab Plus Rivoceranib for Advanced Mixed Hepatocellular-cholangiocarcinoma (HCC-CCA)

PHASE2RecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

August 1, 2027

Study Completion Date

August 1, 2028

Conditions
Mixed Hepatocellular-cholangiocarcinoma
Interventions
DRUG

Camrelizumab

Camrelizumab will be administered by IV, 200 mg every 2 weeks.

DRUG

Rivoceranib (Apatinib)

Rivoceranib will be administered by oral 250 mg once daily.

PROCEDURE

HAIC

FOLFOX regimen (oxaliplatin, 85 mg/m2 from hour 0-2 on day 1; leucovorin, 400 mg/m2 from hour 2-3 on day 1; and fluorouracil, 400 mg/m2 bolus at hour 3 on day 1 and 2,400 mg/m2 over 24 hours) via infusion via the hepatic artery. HAIC was repeated once every 4 weeks for up to 6 cycles. Camrelizumab plus rivoceranib will be administered 1-3 days after HAIC.

Trial Locations (1)

200032

RECRUITING

Zhongshan Hospital, Fudan University, Shanghai

All Listed Sponsors
lead

Fudan University

OTHER

NCT07105748 - HAIC Combined With Camrelizumab Plus Rivoceranib for Advanced Mixed Hepatocellular-cholangiocarcinoma (HCC-CCA) | Biotech Hunter | Biotech Hunter