NCT07104318View on ClinicalTrials.gov

Personalized vs Standard of Care Treatment for Helicobacter Pylori Eradication Among Veterans

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

January 1, 2026

Primary Completion Date

December 1, 2028

Study Completion Date

December 1, 2029

Conditions
Helicobacter Pylori
Interventions
DRUG

Bismuth quadruple therapy with optimized PPI

Bismuth 524mg QID, Metronidazole 500mg QID, Tetracycline 500MG QID, and Omeprazole 20 mg QID for 14 days.

DRUG

Bismuth quadruple therapy with standard PPI

"Bismuth 524mg QID, Metronidazole 500mg QID, Tetracycline 500mg QID, and Omeprazole 20mg (active BID + placebo BID) for 14 days.~\*\*NOTE: placebo tablets are used to maintain the same number of pills in all study arms and preserve blinding"

DRUG

Clarithromycin triple therapy with optimized PPI

Amoxicillin 1000mg (active BID + placebo BID), Clarithromycin 500mg (active BID + placebo BID), and Omeprazole 20mg QID for 14 days. \*\*NOTE: placebo tablets are used to maintain the same number of pills in all study arms and preserve blinding

DRUG

Clarithromycin triple therapy with standard PPI

Amoxicillin 1000mg (active BID + placebo BID), Clarithromycin 500mg (active BID + placebo BID), and Omeprazole 20mg (active BID + placebo BID) for 14 days. \*\*NOTE: placebo tablets are used to maintain the same number of pills in all study arms and preserve blinding

DRUG

Standard bismuth quadruple therapy

Bismuth 524mg QID, Metronidazole 500mg QID, Tetracycline 500mg QID, and Omeprazole 20mg (active BID + placebo BID) for 14 days. \*\*NOTE: placebo tablets are used to maintain the same number of pills in all study arms and preserve blinding

Trial Locations (1)

92161-0002

VA San Diego Healthcare System, San Diego, CA, San Diego

All Listed Sponsors
collaborator

San Diego Veterans Healthcare System

FED

lead

VA Office of Research and Development

FED