Occurrence of Acute Kidney Injury After CAR-T Cells Treatments in B-cell Lymphoma.

Active, not recruitingOBSERVATIONAL
Enrollment

300

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

December 1, 2025

Study Completion Date

April 1, 2026

Conditions
Acute Kidney Injury (AKI)Infusion of CD19 CAR T CellB Cell Lymphoma
Interventions
BIOLOGICAL

Incidence of acute kidney injury

"* Creatinine measurement before lymphodepletion chemotherapy, before CAR-T cells injection (day 0) and at day 1, day 3, day 5, day 7, day 10, day 14, day 21 and day 28.~* AKI according to 2012 KDIGO."

OTHER

Describe risk factors in AKI occurrence.

"Comparison of caracteristics between participants with AKI and participants without AKI :~* Baseline caracteristics of participants : age, gender, BMI (Body mass index), medical history…~* Caracteristics of hematology disease : severity of lymphoma, previous treatments (chemotherapy, autologous/allogenic stem cell transplant), type of CAR-T cells (axi-cel, tisa-cel)~* Other adverse affects : cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS)~* Use of nephrotoxic medications Informations found in medical field."

OTHER

Focus on patient with chronic kidney disease at baseline

Looking at the subgroup with chronic kidney disease at baseline : are the outcomes different in this population ? Efficacity of CAR-T ? More adverse effects ?

OTHER

Long term evolution after treatment by CAR-T cells

Creatinine measurement 1 year after CAR-T treatment. Informations found in medical field.

Trial Locations (1)

69495

Nephrology department, Centre hospitalier Lyon Sud, Pierre-Bénite

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER