300
Participants
Start Date
April 1, 2025
Primary Completion Date
December 1, 2025
Study Completion Date
April 1, 2026
Incidence of acute kidney injury
"* Creatinine measurement before lymphodepletion chemotherapy, before CAR-T cells injection (day 0) and at day 1, day 3, day 5, day 7, day 10, day 14, day 21 and day 28.~* AKI according to 2012 KDIGO."
Describe risk factors in AKI occurrence.
"Comparison of caracteristics between participants with AKI and participants without AKI :~* Baseline caracteristics of participants : age, gender, BMI (Body mass index), medical history…~* Caracteristics of hematology disease : severity of lymphoma, previous treatments (chemotherapy, autologous/allogenic stem cell transplant), type of CAR-T cells (axi-cel, tisa-cel)~* Other adverse affects : cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS)~* Use of nephrotoxic medications Informations found in medical field."
Focus on patient with chronic kidney disease at baseline
Looking at the subgroup with chronic kidney disease at baseline : are the outcomes different in this population ? Efficacity of CAR-T ? More adverse effects ?
Long term evolution after treatment by CAR-T cells
Creatinine measurement 1 year after CAR-T treatment. Informations found in medical field.
Nephrology department, Centre hospitalier Lyon Sud, Pierre-Bénite
Hospices Civils de Lyon
OTHER